Main finding: Latanoprostene bunod ophthalmic solution 0.024% every evening demonstrated significantly greater IOP lowering than timolol 0.5% BID throughout the day over 3 months of treatment in patients with open-angle glaucoma or ocular hypertension.
Purpose: To compare the IOP-lowering effects of Latanoprostene bunod vs timolol in patients with open-angle glaucoma or ocular hypertension.
Study type: Randomized controlled trial
Condition: Open angle glaucoma, Ocular Hypertension
Participants:≥18 years old, open angle glaucoma or ocular hypertension
n=387 patients
Intervention:
Group 1: latanoprostene bunod (LBN) ophthalmic solution 0.024% every evening
Group 2: Timolol 0.5% bd
At all 9 time points (IOP was measured at 8 am, 12 pm, and 4 pm of each follow-up visit ), the mean IOP in the study eye was significantly lower in the LBN 0.024% group than in the timolol 0.5% group.
Outcomes
LBN 0.024%
Timolol 0.5%
Proportion of subjects with mean IOP ≤18 mmHg
22.9%
11.3%
Proportion of subjects with IOP reduction ≥25%
34.9%
19.5%
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