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DRCR.net PROTOCOL AB: Vitrectomy vs Aflibercept for Vitreous Hemorrhage

May 6, 2021

Clinical trial

Visual Acuity, Vitreous Hemorrhage, and Other Ocular Outcomes After Vitrectomy vs Aflibercept for Vitreous Hemorrhage Due to Diabetic Retinopathy: A Secondary Analysis of a Randomized Clinical Trial.

Glassman AR, Beaulieu WT, Maguire MG, Antoszyk AN, Chow CC, Elman MJ, Jampol LM, Salehi-Had H, Sun JK.

JAMA Ophthalmol. 2021 Jul 1;139(7):725-733.
Full text | Metrics.

Main finding: A secondary analysis showed that eyes receiving initial vitrectomy with PRP had faster recovery of vision over 24 weeks when baseline VA was worse than 20/800 and faster vitreous hemorrhage clearance.

 

  • Purpose: To compare initial treatment of vitreous hemorrhage from proliferative diabetic retinopathy with intravitreal aflibercept vs vitrectomy with panretinal photocoagulation
  • Type: Secondary analysis of Randomized controlled Trial
  • Condition: Proliferative diabetic retinopathy

Participants: Type 1/2 diabetes, vitreous haemorrhage from Proliferative diabetic retinopathy, VA 20/32-LP

 

  • n=205

 

Intervention:

 

Group 1: Intravitreal Aflibercept 2mg
Group 2: Vitrectomy with panretinal photocoagulation

There was no significant difference in mean visual acuity letter score over 24 weeks between both groups.

 

Over 2 years, 33% assigned to aflibercept received vitrectomy and 32% assigned to vitrectomy received subsequent aflibercept.

December 15, 2020

Clinical trial

Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial.

Antoszyk AN, Glassman AR, Beaulieu WT, Jampol LM, Jhaveri CD, Punjabi OS, Salehi-Had H, Wells JA 3rd, Maguire MG, Stockdale CR, Martin DF, Sun JK.

JAMA. 2020 Dec 15;324(23):2383-2395.
Full text | Metrics.

Main finding: In patients with vitreous hemorrhage from proliferative diabetic retinopathy, there was no difference in visual acuity over 24 weeks following initial treatment with intravitreal aflibercept vs vitrectomy with panretinal photocoagulation.

 

  • Purpose: To compare initial treatment of vitreous hemorrhage from proliferative diabetic retinopathy with intravitreal aflibercept vs vitrectomy with panretinal photocoagulation
  • Type: Randomized controlled Trial
  • Condition: Proliferative diabetic retinopathy

Participants: Type 1/2 diabetes, vitreous haemorrhage from Proliferative diabetic retinopathy, VA 20/32-LP

 

  • n=205

 

Intervention:

 

Group 1: Intravitreal Aflibercept 2mg
Group 2: Vitrectomy with panretinal photocoagulation

There was no significant difference between groups in mean VA over 24 weeks of follow-up.

 

Eyes receiving initial vitrectomy with PRP had faster recovery of vision over 24 weeks when baseline VA was worse than 20/800 and faster vitreous hemorrhage clearance.

Outcome Baseline VA of 20/32 to 20/160 Baseline VA worse than 20/800
Adjusted mean difference in VA letter score over 24 weeks between −4.3 −16.7

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Updated on March 7th, 2022

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