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Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation

December, 2019

Case series

Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation.

Catapano J, Fung SSM, Halliday W, Jobst C, Cheyne D, Ho ES, Zuker RM, Borschel GH, Ali A.

Br J Ophthalmol. 2019 Dec;103(12):1724-1731.
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Main finding: This minimally invasive corneal neurotisation procedure improved corneal sensation and stabilised corneal epithelium in a small sample of patients with neutrophic keratopathy.

 

  • Purpose: To describe the clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy treated with minimally invasive corneal neurotisation using a sural nerve graft and donor sensory nerves from the face.
  • Study type: Prospective cohort study
  • Condition: Neurotrophic keratopathy

Participants: Neutrotrophic keratopathy secondary to congenital corneal anaesthesia and other causes. NB: 14 patients were ≤18 years

 

  • n=19 eyes of 16 patients

 

Intervention:

 

Minimally invasive corneal neurotisation was performed using a sural nerve graft and donor sensory nerves from the face.

The mean central corneal sensation improved from 0.8 to 49.7 at final follow up, and the number of episodes of corneal epithelial defects were significantly reduced.
The mean BCVA was stable.

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