Central Serous Chorioretinopathy
Last updated: February 21st, 2022
Summary of Evidence
Mineral receptor antagonist
Eplerenone did not significantly improve BCVA in chronic CSCR after 12 months of treatment.(VICI, 2020). {Lotery A, Sivaprasad S, O’Connell A, Harris RA, Culliford L, Ellis L, Cree A, Madhusudhan S, Behar-Cohen F, Chakravarthy U, Peto T, Rogers CA, Reeves BC; VICI trial investigators. Eplerenone for chronic central serous chorioretinopathy in patients with active, previously untreated disease for more than 4 months (VICI): a randomised, double-blind, placebo-controlled trial. Lancet. 2020 Jan 25;395(10220):294-303.}
Photodynamic therapy
PDT vs subthreshold micropulse laser
Half-dose PDT is superior to high-density subthreshold micropulse laser (HSML) treatment in patients with chronic central serous chorioretinopathy.(PLACE, 2018). {van Dijk EHC, Fauser S, Breukink MB, Blanco-Garavito R, Groenewoud JMM, Keunen JEE, Peters PJH, Dijkman G, Souied EH, MacLaren RE, Querques G, Downes SM, Hoyng CB, Boon CJF. Half-Dose Photodynamic Therapy versus High-Density Subthreshold Micropulse Laser Treatment in Patients with Chronic Central Serous Chorioretinopathy: The PLACE Trial. Ophthalmology. 2018 Oct;125(10):1547-1555.}
Crossover to half-dose PDT after previous unsuccessful HSML treatment for CSCR may lead to improved anatomic and functional endpoints, but not vice versa.(PLACE, 2020). {van Rijssen TJ, van Dijk EHC, Scholz P, Breukink MB, Dijkman G, Peters PJH, Tsonaka R, MacLaren RE, Downes SM, Fauser S, Boon CJF, Hoyng CB. Crossover to Photodynamic Therapy or Micropulse Laser After Failure of Primary Treatment of Chronic Central Serous Chorioretinopathy: The REPLACE Trial. Am J Ophthalmol. 2020 Aug;216:80-89.}
Responses