sourcing the best research evidence in ophthalmology
Anti-VEGF intravitreal injection, Macular laser, Intravitreal Triamcinolone, Panretinal photocoagulation
Clinical trials: BRAVO, BVOS, SCORE
Clinical trials: CRUISE, CVOS, SCORE
Anti-VEGF intravitreal injection, Panretinal photocoagulation
Clinical trials: ETDRS, Protocol S, Clarity
Anti-VEGF intravitreal injection, Macular laser, Intravitreal Triamcinolone, Dexamethasone implant
Clinical trials: Protocol V, Protocol I, Protocol T, Protocol B, RISE/RIDE
Ranibizumab, Aflibercept, Bevacizumab, Brolucizumab
Clinical trials: MARINA, ANCHOR, VIEW, CATT, HAWK/HARRIER
Mineral receptor antagonist, Photodynamic therapy, subthreshold micropulse laser
Clinical trials: VICI, PLACE, REPLACE
Loteprednol, Cyclosporine 0.09%, Cyclosporine 0.05%, Lifitegrast 5%, Autologous serum eyedrops.
Clinical trials: OPUS
Antibiotics, corticosteroids
Clinical trial: SCUT
Antifungal, corneal collagen cross-linking
Clinical trial: MUTT I, MUTT II
Antivirals, corticosteroids
HEDS-EKT, SKN, IRT, APT
Conjunctival autograft, fibrin glue
DMEK vs DSEK
DWEK vs DMEK
Clinical trials: AGIS, CIGTS, EMGTS, UKGTS, GITS
Clinical trials: CNTGS, LPGTS
Clinical trials: ZAP, EAGLE
Clinical trials: LIGHT, SALT
iStent, Hydrus, XEN, Preserflo
Clinical trials: COMPARE, HORIZON
Binocular treatment, Atropine, Patching
Clinical trials: PEDIG
Clinical trials: IATS
Clinical trials: PEDIG, ELISS
Long eye, short eye, previous refractive surgery, keratoconus
Barrett Universal II, Kane, Haigis, SRK/T
Risk factors, intracameral/topical antibiotics, vitrectomy
Clinical trials: EVS, ESCRS
Toric intraocular lens, limbal relaxing incisions, astigmatic keratotomy, alignment methods
Risk factors, management, timing of drainage
Clinical trial: Fluorouracil Filtering Surgery Study
LASIK vs SMILE, PRK, LASEK. Surgical techniques. Complications: Post-LASIK estasia, Dry Eye
PRK vs LASIK, LASEK. Transepithelial PRK. Mitomycin-C for corneal haze. Pain management, bandage contact lens
European multicenter trial of the prevention of cystoid macular edema after cataract surgery in nondiabetics: ESCRS PREM...
2018
Femtosecond laser-assisted versus phacoemulsification cataract surgery (FEMCAT): a multicentre participant-masked random...
2020
Results of the Endophthalmitis Vitrectomy StudyA Randomized Trial of Immediate Vitrectomy and of Intravenous Antibiotics...
1995
Prophylaxis of postoperative endophthalmitis following cataract surgery: Results of the ESCRS multicenter study and iden...
2007
Long-Term Outcomes after Surgery for Late In-The-Bag Intraocular Lens Dislocation: A Randomized Clinical Trial
2019
Randomized Clinical Trial Comparing Femtosecond LASIK and Small-Incision Lenticule Extraction
The Steroids for Corneal Ulcers Trial (SCUT): Secondary 12-Month Clinical Outcomes of a Randomized Controlled Trial
2014
n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease
Lifitegrast for the Treatment of Dry Eye Disease: Results of a Phase III, Randomized, Double-Masked, Placebo-Controlled ...
2017
Hyperosmolar Eye Drops for Diurnal Corneal Edema in Fuchs’ Endothelial Dystrophy: A Double-Masked, Randomized Controll...
2021
The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole.
2013
Herpetic Eye Disease Study. A controlled trial of topical corticosteroids for herpes simplex stromal keratitis.
1994
A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex v...
1997
Effect of Corneal Cross-linking versus Standard Care on Keratoconus Progression in Young Patients: The KERALINK Randomiz...
Three-year follow-up of the tube versus trabeculectomy study.
2009
Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 3 Years of Follow-up.
Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a...
A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatm...
Three-Year Findings of the HORIZON Trial: A Schlemm Canal Microstent for Pressure Reduction in Primary Open-Angle Glauco...
Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therape...
1998
The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays...
2002
Laser peripheral iridotomy for the prevention of angle closure: a single-centre, randomised controlled trial.
Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised control...
2016
Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial.
Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized t...
2001
The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual ...
2000
Trial of Tocilizumab in Giant-Cell Arteritis.
A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy.
2011
Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: t...
Randomized Trial of Thymectomy in Myasthenia Gravis. The Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patien...
Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy.
2008
A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis.
1992
Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial.
Treatment of anisometropic amblyopia in children with refractive correction.
2006
Treatment of severe amblyopia with weekend atropine: results from 2 randomized clinical trials.
Complications in the first 5 years following cataract surgery in infants with and without intraocular lens implantation ...
Outcomes of Unilateral Cataracts in Infants and Toddlers 7 to 24 Months of Age: Toddler Aphakia and Pseudophakia Study (...
Spontaneous resolution of early-onset esotropia: experience of the Congenital Esotropia Observational Study.
Final report of the early vs. late infantile strabismus surgery study (ELISSS), a controlled, prospective, multicenter s...
2005
Adalimumab plus Methotrexate for Uveitis in Juvenile Idiopathic Arthritis.
Atropine for the treatment of childhood myopia: safety and efficacy of 0.5%, 0.1%, and 0.01% doses (Atropine for the Tre...
2012
Low-Concentration Atropine for Myopia Progression (LAMP) Study: A Randomized, Double-Blinded, Placebo-Controlled Trial o...
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and ...
Ranibizumab for neovascular age-related macular degeneration.
Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results o...
Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration:...
HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials of Brolucizumab for Neovascular Age-Related Macular D...
Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical ...
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two-year results of a...
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-d...
1993
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complica...
Effect of Intravitreous Anti-Vascular Endothelial Growth Factor vs Sham Treatment for Prevention of Vision-Threatening C...
Aflibercept, Bevacizumab, or Ranibizumab for Diabetic Macular Edema: Two-Year Results from a Comparative Effectiveness R...
Five-Year Outcomes of Ranibizumab With Prompt or Deferred Laser Versus Laser or Triamcinolone Plus Deferred Ranibizumab ...
Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients Wit...
Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A...
Evaluation of Intravitreal Aflibercept for the Treatment of Severe Nonproliferative Diabetic Retinopathy: Results From t...
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