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PEDIG: Atropine vs patching in moderate amblyopia aged < 7 years old

July, 2014

Cohort study

Atropine vs patching for treatment of moderate amblyopia: follow-up at 15 years of age of a randomized clinical trial.

Repka MX, Kraker RT, Holmes JM, Summers AI, Glaser SR, Barnhardt CN, Tien DR.

JAMA Ophthalmol. 2014 Jul;132(7):799-805.
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Main finding: Improvements with amblyopia treatment were maintained at 15 years of age, with similar outcomes in both groups.

 

  • Purpose: To report long-term outcomes of patching and atropine as treatments for moderate amblyopia in children aged below 7 years old.
  • Type: Observational study
  • Condition: Amblyopia

Participants: Long term follow up of unselected subgroup of patient from PEDIG trial comparing Atropine vs patching.

 

  • n=147 patients

At 15-years of age:

 

Mean visual acuity in the amblyopic eye was approximately 20/25; 59.9% had VA of 20/25 or better and 33.3% 20/20 or better

 

Mean interocular acuity difference was 2.1 lines.
There was no significant differences in visual acuity of amblyopic and fellow eyes based on original treatment.

February, 2005

Clinical trial

Two-year follow-up of a 6-month randomized trial of atropine vs patching for treatment of moderate amblyopia in children.

Repka MX, Wallace DK, Beck RW, Kraker RT, Birch EE, Cotter SA, Donahue S, Everett DF, Hertle RW, Holmes JM, Quinn GE, Scheiman MM, Weakley DR.

Arch Ophthalmol. 2005 Feb;123(2):149-57.
Full text

Main finding: Atropine or patching resulted in similar visual improvement in the amblyopic eye at 2 years.

 

  • Purpose: To compare patching and atropine as treatments for moderate amblyopia in children aged below 7 years old.
  • Type: Randomized controlled Trial
  • Condition: Amblyopia

Participants: Children younger than 7 years with amblyopia (Strabismic or anisometropic)

-VA in amblyopic eye 20/40-20/100

-VA in sound eye 20/40 or better

 

  • n=419 patients

 

Intervention:

 

Group 1: Patching (6 hours/day)
Group 2: Atropine 1% (once daily)

March, 2002

Clinical trial

A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children.

Arch Ophthalmol. 2002 Mar;120(3):268-78.
Full text

Main finding: Atropine or patching resulted in similar visual improvement in the amblyopic eye at 6 months.

 

  • Purpose: To compare patching and atropine as treatments for moderate amblyopia in children aged below 7 years old.
  • Type: Randomized controlled Trial
  • Condition: Amblyopia

Participants: Children younger than 7 years with amblyopia (Strabismic or anisometropic)

-VA in amblyopic eye 20/40-20/100

-VA in sound eye 20/40 or better

 

  • n=419 patients

 

Intervention:

 

Group 1: Patching (6 hours/day)
Group 2: Atropine 1% (once daily)

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Updated on March 7th, 2022

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