Descemet membrane endothelial keratoplasty (DMEK)
Edited by: Armand Borovik
Last updated: June 1st, 2022
Summary of Evidence
Descemet membrane endothelial keratoplasty (DMEK) vs Descemet’s Stripping Endothelial Keratoplasty (DSEK)
Meta-analysis of 11 prospective and retrospective studies comparing DMEK vs DSAEK showed:
- No significant difference in endothelial cell loss
- Significantly higher partial detachment rate with DMEK
- DMEK was superior in best-corrected visual acuity after 6 months, subjective evaluation of visual acuity, patient satisfaction, and was the method preferred by patients {Pavlovic I, Shajari M, Herrmann E, Schmack I, Lencova A, Kohnen T. Meta-Analysis of Postoperative Outcome Parameters Comparing Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty. Cornea. 2017 Dec;36(12):1445-1451.}
Evidence
1. Background
1.1 DMEK and glaucoma
2. Techniques
2.1 Sulfur Hexafluoride 20% Versus Air 100% for Anterior Chamber Tamponade
3. Outcomes
3.1 DMEK vs DSAEK/DSEK
3.1.1 Primary
3.1.2 After previous penetrating keratoplasty
3.2 Graft detachment and rebubbling
3.3 Postoperative Endothelial Cell Density and graft survival
References
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