Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).
Main finding: Intensive blood-glucose control by either sulphonylureas or insulin substantially decreases the risk of microvascular complications in patients with Type 2 Diabetes.
Purpose: To evaluate the effects of intensive blood glucose control on microvascular and macrovascular complications in patients with type 2 diabetes
Study type: Randomized controlled trial
Condition: Type 2 Diabetes Mellitus
Participants: 25-65yo, newly diagnosed Type 2 DM
n=3867
Intervention:
Blood glucose control arm:
Group 1: Intensive treatment: Sulphonylurea or insulin, aiming fasting glucose level < 6mmol/L
Group 2: Conventional treatment: Diet
The risk in the intensive group was 12% lower for any diabetes-related endpoint; 10% lower for any diabetes-related death; and 6% lower for all-cause mortality compared to the conventional group.
There was a 25% risk reduction in microvascular endpoints including the need for retinal photocoagulation in the intensive group
September 12, 1998
Clinical trial
UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38.
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