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A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatment of Open-Angle Glaucoma (COMPARE)

January 1, 2020

Clinical Trial

A Prospective Randomized Trial Comparing Hydrus and iStent Microinvasive Glaucoma Surgery Implants for Standalone Treatment of Open-Angle Glaucoma: The COMPARE Study.

Ahmed IIK, Fea A, Au L, Ang RE, Harasymowycz P, Jampel HD, Samuelson TW, Chang DF, Rhee DJ.

Ophthalmology. 2020 Jan;127(1):52-61.
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Main finding: Standalone MIGS in OAG with the Hydrus resulted in a higher surgical success rate and fewer medications compared with the 2-iStent procedure. The 2 MIGS devices have similar safety profiles

 

  • Purpose: To compare the efficacy of Hydrus Microstent and iStent Trabecular Micro Bypass devices for reducing intraocular pressures and medication use in open-angle glaucoma.
  • Study type: Randomized controlled Trial
  • Condition: Open Angle Glaucoma

Participants: 45-84yo, mild-moderate OAG (POAG, PXFG, PDSG)

 

  • n=148

 

Intervention:

 

  • Group 1: Hydrus microstent
  • Group 2: iStent x2

The Hydrus had a greater rate of complete surgical success and reduced medication use (difference = -0.6 medications).

 

More Hydrus subjects were medication free (difference = 22.6%).

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