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Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy

April 11, 2008

Cohort study

Non-arteritic anterior ischemic optic neuropathy: role of systemic corticosteroid therapy.

Hayreh SS, Zimmerman MB.

Graefes Arch Clin Exp Ophthalmol. 2008 Jul;246(7):1029-46.
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Main finding: Use of systemic corticosteroids in the acute phase of NAION resulted in a significantly higher probability of improvement in visual acuity and visual field than in the untreated group.

 

  • Purpose: To investigate the role of systemic corticosteroid therapy in non-arteritic anterior ischemic optic neuropathy
  • Study type: Cohort study
  • Condition: Non-arteritic anterior ischemic optic neuropathy

Participants: NAION

 

  • n=613

 

Intervention:

 

Group 1: Systemic steroids (80 mg Prednisone daily for 2 weeks, and then tapered down to 70 mg for 5 days, 60 mg for 5 days, and then cutting down by 5 mg every 5 days.)
Group 2: Observation

Outcomes Systemic steroids Observation
VA improvement 69.8% 40.5%
Visual field improvement 40.1% 24.5%

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