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Hyperosmolar Eye Drops for Diurnal Corneal Edema in Fuchs’ Endothelial Dystrophy

November 1, 2021

Clinical Trial

Hyperosmolar Eye Drops for Diurnal Corneal Edema in Fuchs’ Endothelial Dystrophy: A Double-Masked, Randomized Controlled Trial.

Zander DB, Böhringer D, Fritz M, Grewing V, Maier PC, Lapp T, Reinhard T, Wacker K.

Ophthalmology. 2021 Nov;128(11):1527-1533.
Full text | Metrics.

Main finding: Resolution of early morning stromal edema was not accelerated by hyperosmolar eye drops, which more frequently caused AEs. These results are not compatible with a clinically relevant effect of hyperosmolar eye drops and do not support their routine use.

 

  • Purpose: To assess the efficacy of hyperosmolar eye drops on corneal edema resolution.
  • Study type: Randomized controlled Trial
  • Condition: Fuchs’ endothelial dystrophy

Participants: Fuchs’ dystrophy patients scheduled for Descemet membrane endothelial keratoplasty.

 

  • n=68

 

Intervention:

 

Group 1: Hyperosmolar eyedrops
Group 2: Artificial tears (placebo)

Decrease in corneal thickness after 1 hour was -10.5 μm in the treatment arm and -11.2 μm in the placebo arm (P = 0.59), indicating no clinically relevant effect of hyperosmolar eye drops on early morning corneal edema.

 

Adverse events, most commonly burning after eye drop application, were more common with treatment (30 eyes) than placebo (1 eye).

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Updated on March 7th, 2022

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