Effect of acetazolamide on visual function in patients with idiopathic intracranial hypertension and mild visual loss: the idiopathic intracranial hypertension treatment trial.
Wall M, McDermott MP, Kieburtz KD, Corbett JJ, Feldon SE, Friedman DI, Katz DM, Keltner JL, Schron EB, Kupersmith MJ.
Main finding: Acetazolamide combined with a weight-reduction diet resulted in improvement of visual field function compared to diet alone.
Purpose: To determine whether acetazolamide is beneficial in improving vision when added to a low-sodium weight reduction diet in patients with Idiopathic Intracranial Hypertension and mild visual loss.
Study type: Randomized controlled trial
Condition: Idiopathic Intracranial Hypertension
Participants: 18-60yo, fulfilled modified Dandy criteriae and had mild visual loss (Mean deviation -2 to -7dB)
n=165
Intervention:
Group 1: Diet (low-sodium weight reduction diet) + Acetazolamide (1g/day, increased by 250mg/week up to max 4g/day)
Group 2: Diet (low-sodium weight reduction diet)
Acetazolamide and diet resulted in significant improvement in pattern mean deviation and papilloedema grade compared to diet alone. The former also resulted in greater vsion-related quality of life (QOL) scores and reduction in weight.
Outcome
Diamox + diet
Diet
Improvement in VF mean deviation
1.43dB
0.71dB
Improvement in papilloedema grade
-1.31
-0.61
Vision-related quality of life
8.33
1.98
Weight loss
-7.5kg
-3.45kg
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