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Hydrus Microstent for Lowering IOP in Glaucoma Patients Undergoing Cataract Surgery (HORIZON)

June 1, 2021

Clinical trial

Three-Year Findings of the HORIZON Trial: A Schlemm Canal Microstent for Pressure Reduction in Primary Open-Angle Glaucoma and Cataract.

Ahmed IIK, Rhee DJ, Jones J, Singh IP, Radcliffe N, Gazzard G, Samuelson TW, Ong J, Singh K; HORIZON Investigators.

Ophthalmology. 2021 Jun;128(6):857-865.
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Main finding: Combined CS and microstent placement for mild to moderate POAG is safe, more effective in lowering IOP with fewer medications, and less likely to result in further incisional glaucoma filtration surgery than CS alone at 3 years

 

  • Purpose: To compare cataract surgery with implantation of Hydrus microstent vs cataract surgery alone in patients with Primary Open Angle Glaucoma.
  • Study type: Randomized controlled trial
  • Condition: Primary Open angle glaucoma

Participants: Visually significant age-related cataract and Primary open angle glaucoma

-modified diurnal IOP 22-34mmHg at baseline

 

  • n=369 eyes

 

Intervention:

 

Group 1: Phacoemulsification + Hydrus Microstent implantation
Group 2: Phacoemulsification alone

Phaco + Hydrus Phaco alone
Mean number of medications 0.4 0.8
Medication-free 73% 48%
Proportion with IOP 18mmHg or less without medications 56.2% 34.6%
Probability of incisional glaucoma surgery 0.6% 3.9%

January 1, 2019

Clinical trial

A Schlemm Canal Microstent for Intraocular Pressure Reduction in Primary Open-Angle Glaucoma and Cataract: The HORIZON Study.

Samuelson TW, Chang DF, Marquis R, Flowers B, Lim KS, Ahmed IIK, Jampel HD, Aung T, Crandall AS, Singh K.

Ophthalmology. 2019 Jan;126(1):29-37.
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Main finding: There was a superior reduction in intraocular pressure and medication use in patients with mild-moderate POAG undergoing cataract surgery and Hydrus microstent implantation vs cataract surgery alone.

 

  • Purpose: To compare cataract surgery with implantation of Hydrus microstent vs cataract surgery alone in patients with Primary Open Angle Glaucoma.
  • Study type: Randomized controlled trial
  • Condition: Primary Open angle glaucoma

Participants: Visually significant age-related cataract and Primary open angle glaucoma

-modified diurnal IOP 22-34mmHg at baseline

 

  • n=369 eyes

 

Intervention:

 

Group 1: Phacoemulsification + Hydrus Microstent implantation
Group 2: Phacoemulsification alone

Time period Phaco + Hydrus Phaco alone
Proportion with unmedicated modified diurnal IOP was reduced by ≥20% 24-months 77.3% 57.8%
Mean reduction in unmedicated modified diurnal IOP 24-months -7.6mmHg -5.3mmHg
Mean number of medications Baseline 1.7 1.7
24-months 0.3 0.7

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Updated on March 7th, 2022

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