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Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE)

October 1, 2016

Clinical trial

Effectiveness of early lens extraction for the treatment of primary angle-closure glaucoma (EAGLE): a randomised controlled trial.

Azuara-Blanco A, Burr J, Ramsay C, Cooper D, Foster PJ, Friedman DS, Scotland G, Javanbakht M, Cochrane C, Norrie J.

Lancet. 2016 Oct 1;388(10052):1389-1397.
Full text | Metrics.

Main finding: Clear-lens extraction showed greater efficacy and was more cost-effective than laser peripheral iridotomy, and should be considered as an option for first-line treatment

 

  • Purpose: To assess efficacy and safety of clear lens extraction and laser peripheral iridotomy in Primary Angle Closure Glaucoma
  • Study type: Randomized controlled trial
  • Condition: Primary Angle Closure/Primary Angle Closure Glaucoma

Participants: ≥50yo, phakic with no cataract, newly diagnosed PAC/PACG, IOP ≥30mmHg

 

  • n=419

 

Intervention:

 

Group 1: Clear Lens extraction
Group 2: Laser PI + topical medications

Quality of life was higher and mean intraocular pressure lower after CLE compared to laser PI/topical medications (1.18mmHg lower)

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