Main finding: The incidence of Angle closure disease was very low in patients who were primary angle closure suspects. Prophylactic laser PI for PACS is not recommended
Purpose: To assess efficacy and safety of laser peripheral iridotomy prophylaxis against primary angle-closure glaucoma in Chinese people classified as primary angle closure suspects
Study type: Randomized controlled trial
Condition: Primary Angle Closure Suspect
Participants: 50-70yo, PACS
Definition of PACS = angle closure ≥6 hours, no PAS, IOP ≤21
n=889
Intervention:
Group 1: Laser PI (in 1 eye)
Group 2: Observation (fellow eye)
The incidence of primary angle closure was 4·19 per 1000 eye-years in treated eyes compared with 7·97 per 1000 eye-years in untreated eyes.
PAC occurred in significantly more untreated eyes (36 vs 19), mostly due to development of PAS.
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