Initial intraocular pressure reduction by mono- versus multi-therapy in patients with open-angle glaucoma: results from the Glaucoma Intensive Treatment Study.
Lindén C, Heijl A, Jóhannesson G, Aspberg J, Andersson Geimer S, Bengtsson B.
Main finding: In newly diagnosed glaucoma patients, intensive treatment with multiple medications + SLT led to considerably greater IOP reduction than stepwise mono‐therapy at 1 month.
Purpose: To compare the effects of mono- or multi-therapy on IOP reduction in newly diagnosed glaucoma
Study type: Randomized controlled trial
Condition: Newly diagnosed glaucoma
Participants: Newly diagnosed glaucoma
n=295 eyes (240 patients)
Intervention:
Group 1: Immediate intensive treatment (multi‐therapy comprising three different IOP‐lowering substances as two medications and 360° selective or argon LTP 1 week later)
Group 2: conventional stepwise treatment starting with mono-therapy
The median IOP reduction was 11.0 in the intensive group and 6.3 in the conventional group at 1 month.
A larger proportion of the multi‐therapy patients reached each target IOP level
Share This Article :
Please provide feedback on content published. Thank you.
Source Archive