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Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus

May 1, 2003

Case series

Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.

Wollensak G, Spoerl E, Seiler T.

Am J Ophthalmol. 2003 May;135(5):620-7.
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Main finding: Progression was stopped in all eyes treated with corneal collagen crosslinking. There was regression in maximal keratometry readings in 70% of eyes.

 

  • Purpose: To evaluate outcomes of corneal crosslinking in keratoconus
  • Study type: Prospective case series
  • Condition: Keratoconus

Participants: Keratoconus

 

  • n=23 eyes (22 patients)

 

Intervention:

 

-central epithelium off
-Riboflavin 0.1% soak
-Ultraviolet-A exposure at 3mW/cm2 for 30mins

Progression of keratoconus was stopped in all eyes.

 

There was regression in 70% of eyes.

 

Visual acuity improved slightly in 65% of eyes.

 

Corneal and lens transparency, endothelial cell density and intraocular pressure was unchanged.

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