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A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa


Main finding: The results support a beneficial effect of vitamin A (15 000 IU/d) and an adverse effect of vitamin E (400 IU/d) on the course of retinitis pigmentosa.

 

Study characteristics:

 

  • Name: “A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa”
  • Purpose: To evaluate if Vitamin A and/or E supplements can affect the course of RP
  • Type: Randomised controlled Trial
  • Condition: Retinitis pigmentosa
  • Year results published: 1993

Participants: Retinitis pigmentosa, BCVA 20/100 or better

 

  • n=601

 

Intervention:

 

Group 1: Vitamin A 15000IU/day
Group 2: Vitamin A 15000IU/day + Vitamin E 400IU/day
Group 3: Trace amounts of both vitamins
Group 4: Vitamin E 400IU/day

The two groups receiving 15 000 IU/d of vitamin A had a slower rate of decline of retinal function than the two groups not receiving this dosage.

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Updated on March 7th, 2022

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