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Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study

September 1, 2007

Cohort study

Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study: methods and findings to date.

Wagner H, Barr JT, Zadnik K.

Cont Lens Anterior Eye. 2007 Sep;30(4):223-32.
Full text | Metrics.

Main finding: At 8 years, there was a 2.03 and 4.06 letter decline in high- and low-contrast BCVA, 1.60D increase in the flat corneal meridian, and 20% incidence of corneal scarring.

 

  • Purpose: To describe natural history of keratoconus including visual outcomes and quality of life.
  • Study type: Prospective cohort study
  • Condition: Keratoconus

Participants: Age ≥ 12yo with corneal signs typical of keratoconus.

 

  • n=1209 patients

BCVA decreased by 2.03 letters for high contrast and 4.06 letters for low contrast acuity

 

10 or more letter decrease in 19% of subjects for high contrast and 31% of subjects for low contrast VA

 

Corneal curvature increased 1.60D in the flat corneal meridian, with 24% demonstrating increases of 3.00D or more.

 

Incidence of corneal scarring was 20%

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Updated on March 7th, 2022

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