Main finding: There was no survival difference attributable to pre-enucleation radiation of large choroidal melanoma
Study name: Collaborative Ocular Melanoma Study (COMS)
Study type: Randomised controlled Trial
Condition: Choroidal melanoma
Participants: Large choroidal melanoma Definition
-Apical height 2mm or greater AND basal diameter 16mm or greater
-Apical height 10mm or greater AND any basal diameter
n=1003
Intervention:
Group 1: Pre-enucleation radiation to globe and orbit
Group 2: Enucleation
5-year data:
No survival difference between pre-enucleation radiation vs enucleation alone
Pre-enucleation radiotherapy
Enucleation
Survival rate
62%
57%
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