Main finding: The use of subconjunctival 5-fluorouracil after trabeculectomy in eyes after previous cataract surgery or unsuccessful filtering surgery decreases failure rate at 5 years.
Purpose: To determine the efficacy and safety of subconjunctival 5- fluorouracil injections after trabeculectomy
Study type: Randomized controlled trial
Condition: Uncontrolled glaucoma
Participants: uncontrolled glaucoma (IOP > 21mmHg), with previous cataract surgery or unsuccessful filtering surgery in a phakic eye
n=213
Intervention:
Group 1: Trabeculectomy
Group 2: Trabeculectomy with postoperative 5-fluorouracil injections (5.0mg in 0.5ml) bd for one week, then once daily for one week.
The failure rate was lower in the 5-FU group (51%) than the standard filtering surgery group (74%).
Patients in the 5-fluorouracil group had a higher risk of late-onset bleb leaks (9%) vs standard filtering surgery (2).
Share This Article :
Please provide feedback on content published. Thank you.
Source Archive