Main finding: Risk factors associated with deterioration include bilateral disease, higher IOP, and disc hemorrhage.
Purpose: To identify risk factors associated with Visual field deterioration.
Study type: Randomized controlled trial
Condition: Open Angle glaucoma
Participants: Newly diagnosed OAG (POAG, PXFG)
n=516
Intervention:
Group 1: Latanoprost 0.005%
Group 2: Placebo
Treatment with latanoprost reduced the hazard ratio for VF deterioration by 58%
Risk factors associated with deterioration include bilateral disease, higher IOP, and disc hemorrhage
Smoking history seemed to be protective against VF deterioration.
April 4, 2015
Clinical trial
Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial.
Garway-Heath DF, Crabb DP, Bunce C, Lascaratos G, Amalfitano F, Anand N, Azuara-Blanco A, Bourne RR, Broadway DC, Cunliffe IA, Diamond JP, Fraser SG, Ho TA, Martin KR, McNaught AI, Negi A, Patel K, Russell RA, Shah A, Spry PG, Suzuki K, White ET, Wormald RP, Xing W, Zeyen TG.
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