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Effect of Loteprednol Etabonate 0.5% on Initiation of Dry Eye Treatment With Topical Cyclosporine 0.05%

September, 2014

Clinical Trial

Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%.

Sheppard JD, Donnenfeld ED, Holland EJ, Slonim CB, Solomon R, Solomon KD, McDonald MB, Perry HD, Lane SS, Pflugfelder SC, Samudre SS.

Eye Contact Lens. 2014 Sep;40(5):289-96.
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Main finding: Patients treated with Lotepredniol etabonate showed significantly more improvement in Ocular Surface Disease Index than those who received artificial tears, and significantly reduced stinging from topical cyclosporine.

 

  • Purpose: To evaluate the effect of loteprednol etabonate vs artificial tears before initiation of cyclosporine A in mild-moderate Dry Eye Disease
  • Study type: Randomized controlled Trial
  • Condition: Dry Eye Disease

Participants: Mild-moderate keratoconjunctivitis sicca

 

n=118 patients

 

Intervention:

 

Group 1: Loteprednol etabonate QID for 2 weeks
Group 2: Artificial tears QID for 2 weeks

After 2 weeks, dose decreased to bd and topical cyclosporine added bd for an additional 6 weeks.

Both groups showed significantly improved Ocular surface disease index scores at 2, 4, and 8 weeks, with significantly more improvement in loteprednol vs artificial tears.

 

Loteprednol etabonate pretreatment also significantly reduced topical cyclosporine stinging

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