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Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) – BRVO

September 14, 2009

Clinical trial

A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6.

Scott IU, Ip MS, VanVeldhuisen PC, Oden NL, Blodi BA, Fisher M, Chan CK, Gonzalez VH, Singerman LJ, Tolentino M.

Arch Ophthalmol. 2009 Sep;127(9):1115-28.
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Main finding: Grid photocoagulation remains the standard of care for macular oedema secondary to BRVO; There was no difference in visual outcomes between laser and intravitreal triamcinolone, but with higher rates of adverse events in the latter.

 

  • Purpose: To compare the efficacy and safety of intravitreal triamcinolone with standard of care (grid photocoagulation) for macular edema secondary to branch retinal vein occlusion.
  • Study type: Randomized controlled trial.
  • Condition: Branch retinal vein occlusion

Participants: Centre-involving macular oedema secondary to BRVO, BCVA 20/40-20/400, mean central subfield thickness ≥250 μm

 

  • n=411

 

Intervention:

 

Group 1: Grid photocoagulation
Group 2: Intravitreal Triamcinolone 1mg
Group 3: Intravitreal Triamcinolone 4mg

Outcomes Laser IVTA 1mg IVTA 4mg
VA gain ≥ 15 letters from baseline 29% 26% 27%

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