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Transepithelial corneal collagen crosslinking for progressive keratoconus: 24-month clinical results

August, 2013

Case series

Transepithelial corneal collagen crosslinking for progressive keratoconus: 24-month clinical results.

Caporossi A, Mazzotta C, Paradiso AL, Baiocchi S, Marigliani D, Caporossi T.

J Cataract Refract Surg. 2013 Aug;39(8):1157-63.
Full text | Metrics.

Main finding: Functional results showed instability of keratoconus at 2 years, with functional regression in patients aged 19-26years old.

 

  • Purpose: To evaluate outcomes of transepithelial corneal crosslinking in patients 26 years of age and younger
  • Study type: Prospective case series
  • Condition: Keratoconus

Participants: Age ≤ 26yo, progressive keratoconus

 

  • n=26 eyes (26 patients)

 

Intervention:

 

– Solution for transepithelial CXL (Ricrolin TE): riboflavin 0.1%, dextran 15.0%, trometamol (Tris), and ethylenediaminetetraacetic acid.
-Ultraviolet-A exposure at 3mW/cm2

Uncorrected and corrected distance acuity returned to baseline preoperative values at 2 years.

 

Maximum keratometry worsened at 2 years after 1 year of stability.

 

Pachymetry significantly decreased at 2 years.

 

50% of paediatric patients were re-treated with epi-off CXL due to significant deterioration of all parameters

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